.Nature Medication, Published online: 18 September 2024 doi:10.1038/ s41591-024-03300-3Genomic and epidemiologic reviews revealed that an unfamiliar reassortant virus-like lineage of the Oropouche infection, which has actually been spreading in the western Amazon area of South america for about a years, is connected with the recent human break outs between 2022 as well as 2024.